Position Description

Scientist/Senior Scientist, Metabolism
Location Agios Pharmaceuticals HQ
Job Code 1511
# of openings 1
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Scientist/Senior Scientist, Metabolism 

Agios (agios.com) is a biopharmaceutical company focused on providing medicines for some of the world’s most challenging diseases. We’re committed to applying our scientific leadership in cellular metabolism to transform the lives of patients with genetically defined diseases (GDD), encompassing both rare and more common diseases, and mining the extensive potential in the PK platform. We are leading the way in advancing PKR activation for hemolytic anemias, including pyruvate kinase (PK) deficiency, thalassemia and sickle cell disease, and have demonstrated a strong commitment to these patient communities. We continue to foster a productive research engine that yields new insights and potential therapeutic approaches. We’re a company that cares about our work, each other, and the people who are counting on us the most. We’re inspired to think big and welcome the different perspectives and backgrounds needed to deliver extraordinary results. We’re driven to be our best selves, together, so we can reach for the Other Side of Possible.

We are searching for a dynamic Scientist/Senior Scientist to join our growing Metabolism and Proteomics team.  You will be responsible for the design and execution of metabolomics, lipidomics and targeted LC MS experiments to support drug discovery efforts genetically defined diseases.  You will have the ability to work cross-functionally as a contribution member to our pre-clinical project teams.  

The Metabolism and Proteomics department focuses on quantitatively understanding cellular metabolism, relying on state-of-the-art mass spectrometry methods for proteomics, lipidomics, metabolomics and isotopic labeling studies. Our work includes evaluating disease targets, biological models and characterization of biomarkers to support drug discovery. The successful candidate will have a strong ability to operate and maintain mass spectrometry instrumentation while leveraging their understanding of metabolism to support drug discovery across the portfolio.   

Key Responsibilities 

  • Design and execute metabolomic assays to assess perturbations in cellular metabolism in a variety of disease settings 
  • Develop metabolomic and targeted LCMS methods to support project needs  
  • Improve and troubleshoot established LCMS methods, from sample processing to data analysis. 
  • Analyze data using commercial, open-source, and proprietary computational techniques for understanding target pathways, discovering biomarkers, and analyzing metabolic flux data.   
  • Collaborate with internal groups, such as Cell Biology, Data Sciences, DMPK, Biochemistry, Pharmacology and Clinical, as well as external groups from academia and CROs.   
  • Communicate data to project reps, scientific teams, senior management, and the external community through scientific journals and conferences.  Have responsibility for sharing results with program teams and publishing.   

Minimum Requirements 

  • PhD or postdoc with 4-6 years post graduate experience
  • 2+ years in using LC-MS to evaluate biomarkers in disease metabolism, DMPK, bioanalysis, natural products, or biomarker research.   
  • Proven track record of developing novel LC/MS methods to solve complex biological problems in a discovery research environment, including publications that demonstrate analytics supporting biology or clinical research 
  • Self-motivated and able to work independently or in a small team with minimal supervision.  
  • Excellent communication and organizational skills. 
  • Excellent problem-solving skills and ability to multi-task.

Preferred Qualifications 

  • Experience with metabolomics/lipidomics 
  • Basic understanding of cellular metabolism in relation to disease progression 
  • GC and GC/MS experience 
  • Mammalian cell culture experience 
  • Variety of analytical chemistry experience applied to the analysis of biomolecules 
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