Career Opportunities

Position Description

Scientist – Protein Modeling, Design, and Engineering, Early Drug Discovery
Job ID 11232
Location Waltham, MA
Field Locations
Apply Now

Scientist – Protein Modeling, Design, and Engineering, Early Drug Discovery

Alkermes Overview

Alkermes, Inc. is the U.S. operating company of Alkermes plc, a fully integrated, global  biopharmaceutical company that applies its scientific expertise and proprietary technologies to research, develop and commercialize, both with partners and on its own, pharmaceutical products that are designed to address unmet medical needs of patients in major therapeutic areas. Alkermes has a diversified portfolio of marketed products focused on central nervous system disorders such as addiction and schizophrenia and a pipeline of product candidates in the fields of neuroscience and oncology. Headquartered in Dublin, Ireland, Alkermes has a research and development (“R&D”) center in Waltham, Massachusetts; an R&D and manufacturing facility in Athlone, Ireland; and a manufacturing facility in Wilmington, Ohio.

The following position is for Alkermes, Inc.

Position Description:  Alkermes is searching for a highly talented Scientist responsible for developing and evaluating cutting-edge technologies and concepts for protein modeling and engineering. The newly designed proteins are expected to be the first- or best-in-class biologics to support early drug discovery in multiple disease areas, including oncology, immunology, fibrosis and others.



  • Protein modeling and in silico design efforts to support ongoing protein engineering projects.
  • Identify cutting-edge technologies or methodologies to enable novel protein design and engineering for specific functional goals.
  • Ability to assess newly engineered proteins in biophysical and/or cellular assays
  • Ability to produce newly engineered proteins in high-throughput and small scale from HEK/CHO systems
  • Support IP protection and publications.



  • Protein computational modeling, design & engineering
  • In-depth understanding of protein structure-function, knowledge in Rosetta is a plus
  • Hands-on experience in protein expression and production
  • Experience with external vendors and CROs is a plus
  • Experience in early drug discovery, especially target identification and validation
  • Knowledge in immunology, oncology is a plus


  • Ability to rapidly learn and apply techniques
  • Ability to independently drive projects
  • Scientific creativity
  • Sense of urgency (self-motivation)
  • Strong interdisciplinary communication skills


  • PhD in a relevant scientific discipline (chemistry, biochemistry, biophysics, biology)


 Alkermes, Inc. is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, gender expression and identity, disability, genetic information, veteran status, military status, application for military service or any other class protected by state or federal law.  Alkermes also complies with all work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Alkermes is an E-Verify employer.



Experience Level:
Entry Level
Back Apply Now